ChloroquineV1, Main, Exploration, bibRecord, 000717

Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis

Identifieur interne : 000717 ( Main/Exploration ); précédent : 000716; suivant : 000718

Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis

Auteurs : Nicole Yang [États-Unis] ; Jie Huang [États-Unis] ; Michelle Frits [États-Unis] ; Christine Iannaccone [États-Unis] ; Michael E. Weinblatt [États-Unis] ; Nader Rifai [États-Unis] ; Nancy Shadick [États-Unis] ; Gary Bradwin [États-Unis] ; Katherine P. Liao [États-Unis]

Source :

Practical Laboratory Medicine [ 2352-5517 ] ; 2019.

RBID : PMC:6527918

Abstract

Objective

Soluble Tumor Necrosis Factor Receptor II (sTNFR2) is used as a biomarker to study cardiovascular disease (CVD) in diverse populations. TNF inhibitors (TNFi's) are a common treatment for inflammatory conditions. The objective of this study was to examine whether TNFi use impacts measured sTNFR2 levels.

Methods

We studied blood samples from a cohort of RA patients with clinical data and high sensitivity-C-reactive protein (hsCRP) measurements. To assess for interference, we tested the entire cohort for the expected positive correlation between sTNFR2 and TNFi using Pearson correlations. We then performed Pearson correlations between sTNFR2 and TNFi and sequentially removed subjects on adalimumab, etanercept, and infliximab; if interference was occurring, no correlation would be observed between hsCRP and sTNFR2, and correlation would be restored by removing subjects on the treatment causing the interference.

Results

We studied 190 subjects, 84.2% female, 73.4% anti-CCP positive. All subjects with sTNFR2 level exceeding measurable level were on etanercept. The expected positive correlation between hsCRP and sTNFR2 was not observed when assessing the entire cohort, r = 0.05, p = 0.51. However, the expected correlation was restored only after excluding subjects on etanercept, r = 0.46, p < 0.0001, and not adalimumab or infliximab. ELISA for sTNFR2 was performed using etanercept only and demonstrated direct binding to sTNFR2.

Conclusions

Our data identified interference between etanercept and the TNFR2 assay. Of the TNFi's, only etanercept has a TNF-binding domain modeled after TNFR2. These data should be considered when designing studies using sTNFR2 in populations where etanercept is a treatment option.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527918

DOI: 10.1016/j.plabm.2019.e00122
PubMed: 31193412
PubMed Central: 6527918

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Rifai, Nader" sort="Rifai, Nader" uniqKey="Rifai N" first="Nader" last="Rifai">Nader Rifai</name>
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<author><name sortKey="Bradwin, Gary" sort="Bradwin, Gary" uniqKey="Bradwin G" first="Gary" last="Bradwin">Gary Bradwin</name>
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<author><name sortKey="Liao, Katherine P" sort="Liao, Katherine P" uniqKey="Liao K" first="Katherine P." last="Liao">Katherine P. Liao</name>
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<country xml:lang="fr">États-Unis</country>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>Soluble Tumor Necrosis Factor Receptor II (sTNFR2) is used as a biomarker to study cardiovascular disease (CVD) in diverse populations. TNF inhibitors (TNFi's) are a common treatment for inflammatory conditions. The objective of this study was to examine whether TNFi use impacts measured sTNFR2 levels.</p>
</sec>
<sec><title>Methods</title>
<p>We studied blood samples from a cohort of RA patients with clinical data and high sensitivity-C-reactive protein (hsCRP) measurements. To assess for interference, we tested the entire cohort for the expected positive correlation between sTNFR2 and TNFi using Pearson correlations. We then performed Pearson correlations between sTNFR2 and TNFi and sequentially removed subjects on adalimumab, etanercept, and infliximab; if interference was occurring, no correlation would be observed between hsCRP and sTNFR2, and correlation would be restored by removing subjects on the treatment causing the interference.</p>
</sec>
<sec><title>Results</title>
<p>We studied 190 subjects, 84.2% female, 73.4% anti-CCP positive. All subjects with sTNFR2 level exceeding measurable level were on etanercept. The expected positive correlation between hsCRP and sTNFR2 was not observed when assessing the entire cohort, r = 0.05, p = 0.51. However, the expected correlation was restored only after excluding subjects on etanercept, r = 0.46, p < 0.0001, and not adalimumab or infliximab. ELISA for sTNFR2 was performed using etanercept only and demonstrated direct binding to sTNFR2.</p>
</sec>
<sec><title>Conclusions</title>
<p>Our data identified interference between etanercept and the TNFR2 assay. Of the TNFi's, only etanercept has a TNF-binding domain modeled after TNFR2. These data should be considered when designing studies using sTNFR2 in populations where etanercept is a treatment option.</p>
</sec>
</div>
</front>
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<name sortKey="Frits, Michelle" sort="Frits, Michelle" uniqKey="Frits M" first="Michelle" last="Frits">Michelle Frits</name>
<name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<name sortKey="Iannaccone, Christine" sort="Iannaccone, Christine" uniqKey="Iannaccone C" first="Christine" last="Iannaccone">Christine Iannaccone</name>
<name sortKey="Liao, Katherine P" sort="Liao, Katherine P" uniqKey="Liao K" first="Katherine P." last="Liao">Katherine P. Liao</name>
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<name sortKey="Shadick, Nancy" sort="Shadick, Nancy" uniqKey="Shadick N" first="Nancy" last="Shadick">Nancy Shadick</name>
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HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000717 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:6527918
   |texte=   Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:31193412" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

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Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis

Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis

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Pour générer des pages wiki

	Serveur d'exploration Chloroquine
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